Peptides reloaded - new strategies for tolerogenic vaccination

Invasive diseases: new vaccines and vaccination strategies.

Smallpox vaccines: New formulations and revised strategies for vaccination.

Smallpox has been eradicated but stockpiles of the causative infectious agent, variola virus, have been maintained over decades. Today, the threat of accidental or intentional poxvirus release is accompanied by the fact that the existing licensed smallpox vaccines cause rare but severe adverse reactions yet are the only products with approved efficacy against smallpox. New safer vaccines and ne...

PTH Reloaded: A New Evolutionary Perspective

The parathyroid hormone (PTH) family is a group of structurally-related secreted peptides involved in bone mineral homeostasis and multitude of developmental processes in vertebrates. These peptides mediate actions through PTH receptors (PTHRs), which belong to the transmembrane G protein-coupled receptor group. To date, genes encoding for PTH and PTHR have only been identified in chordates, su...

PubMed reloaded: new interface, enhanced discovery.

The aim of this contribution was to present the redesigned version of the worldwide known PubMed interface. The changes relate to a simplified visualization, in order to require less efforts to find resources; they do not concern the functionalities or the search processing. This brief article will focus on the main differences between the old and the new version.

Cell penetrating and transytosing peptides: powerful strategies for oral insulin delivery

 Insulin is essential for type 1 and advanced type 2 diabetes to maintain blood glucose levels and increase the patient’s longevity. Frequent subcutaneous insulin injections are usually associated with pain, local tissue necrosis, infection and nerve damage. Recently, a number of new delivery methods such as oral insulin delivery have been developed to overcome these limitations and increase pa...